B of internal capsule-PIC, MC1 and MWM1medial cortex and medial

B of internal capsule-PIC, MC1 and MWM1medial cortex and medial white matter at the level of the centrum semiovale, MC2 and MWM2-medial cortex and medial white matter at the level of the high convexity area.Scheel et al. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2013, 21:23 http://www.sjtrem.com/content/21/1/Page 5 of1.4 1.3 1.2 1.1 1.0 0.9 0.8 0.7 good outcome poor outcomeGWR0 - 6h6 - 24h Time24h - 7dFigure 2 GWR time dependency with respect to outcome. GWR median and interquartile range are shown for different time points. Circles denote individual Staurosporine patients. CPC 1? was defined as good outcome, CPC 3? as poor outcome.was obtained within 24 hours and the majority of patients with GWR 97 g/L NSE 97 g/L SSEP absent SSEP detected 67 84 98 CPC 3? `poor' 23 38 26 23 25 19 CPC 1? `good' 0 37 0 35 0 23 56.8 54.8 53.1 60.3 37.7 49.3 Sensitivity NPVsign obtained prospectively very early after cardiac arrest [16]. Only one of 52 patients with LOB sign and none of 20 patients with sulcal effacement sign survived with good outcome. These data corroborate the high specificity of early CT signs for poor outcome prediction. Wu et al. investigated a semi-automated procedure, which used co-registration of CT to a brain atlas and determination of Hounsfield units for several brain regions [15]. In a large cohort, the authors demonstrate that whole brain Hounsfield units obtained from early CCT (most within 24 hours) improved the predictive accuracy of a clinical examination. In this study, only 12 of patients had received hypothermia treatment, and therefore results should be interpreted with care for this patient group. The majority of CCTs in our study were performed on admission, frequently within a few hours after cardiac arrest. Metter et al. did not find a significant association of attenuation with time since cardiac arrest within a narrow time frame of 24 hours [17]. The distribution of GWR over time in our study, however, suggests that GWR may decrease over the days following cardiac arrest for patients with severe hypoxic-ischemic encephalopathy (Figure 2). Similarly, Wu et al. found a significant decrease in the density of the putamen for CT performed within 24?2 hours as compared to within the first 24 hours after cardiac arrest [15]. No difference was PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/7500280 found for other regions, but only few CTs (4 ) were performed after day two, hence the powe.